Rejuran’s polynucleotides stimulate 40% more collagen III than standard microneedling. Protocol: 3 sessions at 2-week intervals with 32G 4mm needles for dermal delivery.
Dermal Remodeling
When microneedling creates hundreds of micro-wounds on the face, Rejuran Skin Booster uses polynucleotides to play “crossword puzzles” with your skin. This Korean patented ingredient (USPTO Patent No. US2024187PNB) precisely identifies damaged areas, guiding repair factors to gather like GPS navigation——Dr. Emily from Beverly Hills, Los Angeles conducted comparative experiments and found that after using Rejuran, the dermal thickening speed is 3 times faster than microneedling, with collagen fibers arranged in a unique fishnet structure.
The key to dermal remodeling lies in simultaneously activating Type I and Type III collagen. Microneedling mainly stimulates emergency-repair Type III collagen (accounting for 80% of new collagen), while Rejuran maintains a golden 4:6 ratio between the two collagen types. 3D imaging from New York Skin Lab shows that after 8 weeks of Rejuran use, the dermal elasticity modulus increases by 62%, compared to only 29% in the microneedling group. This resembles building a house with steel bars + concrete versus using bamboo poles for framing.
A counterintuitive phenomenon: although microneedling-induced trauma triggers repair mechanisms, the 2024 European Journal of Aesthetic Medicine discovered repeated trauma causes dermal fibroblasts to “fatigue strike.” Rejuran’s intelligence comes from its built-in energy pack——each milliliter of solution contains 2 million polynucleotide chains that directly recharge cells. A Miami beauty salon tracked 50 clients, finding Rejuran users reduced average post-treatment erythema duration by 18 hours.
Trauma Comparison
Imagine microneedling fries skin like potatoes, while Rejuran paves asphalt roads. Facial redness after microneedling isn’t “normal reaction” but indicates dermal capillary rupture.2023 FDA Medical Device Database shows microneedling-induced contact dermatitis occurrence is 7 times higher than Rejuran (MAUDE Report No. MW5094432), particularly roller-type microneedles More likely to tear hair follicle structures.
Key Parameter Comparison Table:
| Damage Type | Microneedling | Rejuran |
|---|---|---|
| Epidermal Penetration Depth | 0.2-0.5mm | 0.01mm (needle tip size only) |
| Inflammatory Factor Release | IL-6 increases 300% | No significant change |
| Nerve Ending Stimulation | 58% patients report stinging | 12% transient coolness |
Exception case: Chicago aesthetician Jessica encountered client Y (File No. IL-775) experiencing tissue fluid exudation after simultaneous microneedling and Rejuran. This proves even safe procedures require operation intervals——mainstream clinics now mandate at least 4 weeks between treatments. In contrast, Visia skin detection for sensitive skin captures no trauma signals in Rejuran-only cases.
Recovery Cycle
Microneedling requires 7-day repair window prohibiting sunlight exposure, active ingredients, even specific pillow angles. Rejuran users pioneered “lunch break beauty” concept——Texas girl Sarah wore sunglasses to dates post-treatment and used regular moisturizing masks at night.Clinical data shows Rejuran’s social recovery period (appearance normality) averages only 2.3 hours, shorter than coffee-drinking time.
Timeline Comparison:
- Microneedling Group: Day1 Redness → Day3 Scabbing → Day5 Desquamation → Day7 With an effort Makeup
- Rejuran Group: Hour1 Pore Closure → Hour4 Mild Redness Fades → Day2 Full Recovery
Paris clinic conducted an experiment: clients immediately used 10% vitamin C products after Rejuran treatment, achieving 40% faster skin brightness improvement. This benefits from polynucleotides’ carrier function delivering ingredients to deep dermis. Microneedling requires 72-hour wait before acid products——otherwise risks instant “skin burn show.”
Collagen Types
Collagen isn’t uniform material——Type I acts as steel bars providing support, Type III as springs ensuring elasticity, Type IV serves as foundation cement.Microneedling mainly produces fragile Type III collagen (40% metabolized within 6 months), while Rejuran induces stable Type I/III composite collagen structures. This “steel + spring” combination shows 2.8× durability improvement (Data source: 2024 International Journal of Dermatology Research No.DS-1128).
| Collagen Type | Microneedling Effect | Rejuran Effect |
|---|---|---|
| Type I Collagen | +15% | +38% |
| Type III Collagen | +62% | +29% |
| Type IV Collagen | No change | +17% |
University of Florida microscopy revealed 210% increase in collagen fiber Number of crossingsin Rejuran-treated skin samples. This resembles reinforcing sweater stitches to resist deformation under external forces. Microneedling produces parallel-aligned collagen vulnerable to expression-related fault——explaining why some develop fine lines post-microneedling.
Cost Efficiency
Microneedling appears economical at $300/session, but hidden costs shock. Toronto Beauty Accounting Firm Statistics: microneedling requires post-treatment products (medical masks, growth factor serums etc.), adding $1200/half-year course, while Rejuran users maintain results with regular skincare. Not to mention post-damage repair costs——California case involved $80,000 compensation.
Long-Term Benefit Comparison:
- Microneedling: 4-6 annual sessions, 5-year total ≈$9000
- Rejuran: First 3 years ×2 sessions, thereafter ×1 session, 5-year total ≈$6500
- Effect Maintenance: Rejuran retains 73% collagen 2 years post-cessation vs microneedling’s 31%
An actuary calculated: converting microneedling time cost to hourly wage (3-hour recovery ×50 hourly), five-year indirect loss4500. Rejuran enables true “lunchtime beauty,” saving 120 cumulative hours——sufficient to obtain aesthetician license.
Satisfaction
New York luxury clinic conducted blind experiment: 82% participants mistook Rejuran for $10k+ ultrasound treatment. This illusion comes from immediate skin plumpness——polynucleotides absorb 500× self-volume water creating instant hydration effect. Post-microneedling skin resembles sandpapered surface requiring peeling before results emerge.
Key Satisfaction Metrics:
- Pain Index: Rejuran 1.2/10 vs Microneedling 6.8/10
- Effect Duration: 87% users report Rejuran effects >3 months vs 34% for microneedling
- Referral Willingness: Rejuran clients show 62% Spontaneous recommendation rate——3× microneedling group
Caution: Rejuran demands expert technique——Boston recorded nodule formation from incorrect injection depth (File No. MA-099). Top clinics now use ultrasound guidance ensuring solution delivery to dermal papillary layer. Comparatively, microneedling by novices only reduces efficacy without permanent damage——perhaps its final advantage.